For the past several decades, cancer patients have been fighting for effective treatment that could effectively suppress cancer growth. The traditional chemotherapy drugs often trigger severe side effects that are very hard to live with, and they are not effective in many cases. Now, a new study published in the journal Oncotarget, showed that certain components of marijuana could be used to target and kill cancer cells. The compounds, called cannabinoids, bind to receptors in the body that are linked to inflammation, a condition known as “inflammation syndrome”, and the study showed that cannabinoids could suppress cancer growth.
An interesting study published in the journal Molecular Cancer Therapeutics this week appears to confirm that cannabis compounds kill cancer cells.There is talk of the usefulness of cannabis for many medical problems, such as spastic disorders, neurodegenerative diseases, fatigue, anxiety, microbial diseases, sleep disorders, blood pressure and blood sugar regulation, etc. One of the most interesting points of the study concerns cancer: A recent study has shown that certain compounds in cannabis can kill cancer cells.
Marijuana is powerful, both medicinally and recreationally. Whether you’re using the right blend of cannabis ingredients to fight cancer or simply to calm down after a long day at work, it’s important to have the product of your choice. For many, using delta-8 THC is preferable to delta-9 because it has fewer psychoactive effects and is less anxious and drowsy. So for those trying to solve the problem, Delta-8 is often the first choice. We support this new THC brand and have a selection of Delta-8 THC offers to get you started, whether you are a healthy patient or just want to relax.
New research on cannabis and cancer
The idea of using cannabis as a cure for cancer has been around for some time, but the world has often been hesitant to embrace it. For example, cannabis has been promoted against cancer for many years, and a recent study showed that certain parts of the cannabis plant can kill cancer cells. While not yet a medical rule, this latest study is a powerful weapon in the overall debate about cannabis and cancer.
This study was published in March 2021: Specific compositions of Cannabis sativa compounds have cytotoxic activity and inhibit the motility and colony formation of human glioblastoma cells in vitro. The study investigates the effects of specific combinations of cannabinoid fractions on glioblastoma cells (GBM), a type of brain cancer. Although it is known that some phytocannabinoids can induce cell death, it is somewhat more difficult to find the exact configuration of cannabinoids for optimal exposure, so this issue is currently under investigation.
The reason why the term phytocannabinoids is used here instead of cannabinoids is that this study examines compounds derived directly from noncarboxylated plant material. Decarboxylation is a chemical process (usually involving heat) in which a compound loses a carboxyl group and is converted into another compound. The version we are most familiar with is the decarboxylation of THCA to THC. THC is a cannabinoid, THSA is a phytocannabinoid.
In this particular study, published in March, scientists identified specific fractions of the cannabis strain that are particularly effective in reducing the viability and motility of GBM cells in humans. Translated, this means that they reduce the ability of cancer cells to survive and move. Specific cannabinoid fractions not only suppressed viability and motility, but also reduced the ability of cancer cells to form colonies in two- and three-dimensional models.
These colonies are associated with increased resistance to existing medical treatments. According to this study, cannabis treatment can suppress the formation of these GBM neurospheres, making treatment more feasible. Consider the colonies formed by bacteria such as MRSA and the difficulty of controlling them due to biofilms. Well, it’s a similar concept, making these cells just as hard to reach.
In addition to what is described above, the same compounds were also able to kill glioma stem cells taken from tumor samples, confirming that cannabis compounds are able to kill cancer cells. According to the researchers: The efficacy of cannabis fractions and combinations of active ingredients should be investigated in preclinical and clinical studies in GBM. This study shows the importance of using the right part of the plant to fight cancer.
Is the GBM really that bad?
Yes, it’s true. This form of cancer, glioblastoma, is the most common type of malignant brain tumor, accounting for 47.7% of cases. The incidence of glioblastoma is 3.2 cases per 100,000 population. These brain tumors are very aggressive and grow rapidly. Although this cancer does not usually spread to distant organs, it can affect nearby brain tissue. GBM requires immediate intervention because it can be fatal in less than six months if left untreated.
These tumors are particularly difficult to treat for the following reasons: Localisation to hard-to-reach sites, resistance to standard treatments, insufficient recovery of the brain, damage to neighbouring brain tissue, leakage from the tumour leading to fluid accumulation around the tumour and intracranial hypertension, interruption of the blood supply through the tumour making treatment difficult, epileptic seizures caused by the cancer, and neurotoxicity of existing treatments
These cancers are not easy to overcome and are associated with an unfortunate number of deaths. In general, about 40% survive the first year after diagnosis and only 17% survive the second year. Tumors can be diagnosed with different types of MRI scans, and the cancer is usually treated with a combination of surgery, radiation and chemotherapy. Because tumor cells infiltrate adjacent cells, it is virtually impossible to remove the entire tumor during surgery, so radiation and chemotherapy are necessary. The surgery usually takes the form of a craniotomy, which is the opening of the skull, and because doctors must be careful not to remove parts that could further damage the brain, the surgery is sometimes performed while the patient is conscious.
Once the wound from the surgery has healed, the next step in regular treatment will be radiation therapy, which targets the tumor cells still present in the brain. It damages cancer cells, damaged brain cells and also healthy brain cells. It should be noted that a prognostic factor for the development of glioblastoma is previous therapeutic irradiation, i.e., one cancer treatment may cause the same cancer, and irradiation from other cancer treatments may cause glioblastoma. The result is a certain complexity in thinking about how to deal with it.
Some patients also receive chemotherapy in the form of the drug temozolomide. This medicine is taken during radiation therapy and for six cycles after treatment, with each cycle lasting 28 days. To give an idea of the extreme nature of this drug, it is administered only during the first five days of the cycle, followed by 23 days of rest.
Should we expect cannabis to kill cancer?
Some of the most important medical discoveries about cannabis relate to its ability to help fight cancer in a variety of ways. Killing cancer cells is one thing, dealing with the depletion that comes with cancer treatment (as well as HIV and other diseases or treatments that affect appetite and the ability to eat) is another. It can help manage nausea and vomiting associated with cancer or its treatment, as well as the pain caused by various cancers or their treatment. Finally, it can help the body process and heal from the effects of these diseases and treatments.
The most important of these, of course, is its ability to kill cancer cells safely and with less damage. When looking at cannabis and cancer in general, we have reason to believe that cannabis may be effective in killing many different types of cancer cells. Take the example of GBM, an aggressive brain tumor that currently responds well to a specific cannabinoid cocktail. But we already have data on other cancers for which cannabis may be useful. In fact, there are many reasons to believe that almost all cancers can respond to appropriate treatment with cannabis, and this has been demonstrated in the studies cited.
Specific areas of cancer and cannabis research include skin cancer, where cannabis has been shown to be effective in some cancers, and the pain associated with these cancers. Brain tumors, in both children and adults, are currently the subject of millions of dollars of research as more and more studies support the effectiveness of treatments. Its efficacy has also been demonstrated in melanoma patients, leading Cannabics Pharmaceuticals to develop specific antitumor medications for melanoma patients.
But Cannabics went even further: This year, it also announced the results of a trial of RCC-33, a drug the company has developed to treat colorectal cancer. To give an idea of Cannabics’ belief that cannabis can be used to fight different types of cancer, the company recently filed patent applications for proprietary treatments for different types of cancer.
While I could write a dozen articles just about cannabis and cancer research, I will end this section with a heartbreaking article that demonstrates the need for these drugs. A few years ago, it was reported that Dr. William Courtney of the International Cannabis Foundation had helped a father cure cancer in his eight-month-old baby by applying CBD oil to his nipple. Courtney commented: This child… will not have the long-term side effects that can occur with very high doses of chemotherapy or radiation.
While we don’t often make statements in the medical community, I think the claim that cannabis helps fight cancer can now be said more freely. No matter how long it takes for this to become common knowledge, this time does not affect the plant’s ability to fight cancer. I hope that the registration will be faster, because many people need this help.
Research in this area continues and as more and more patients report positive results with cannabis preparations, it is hoped that with some research and development, these could soon be the first drugs offered to cancer patients. Although it is not possible to make medical claims, it seems that cannabis can kill cancer.
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